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trials used a stepwise dose-escalation approach at Q4W In TRIUMPH-3, 12mg reduced TGs, non-HDL cholesterol, systolic BP, waist circumference, & hsCRP by 37%, 16.5%, 9.3mmHg, 19cm, & 51.2%, respectively

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The association was strongest in the first 30 days and remained significant at 12 months

Abouleisa, R