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DPP4 inhibitors produce direct vasodilatory effects in isolated preconstricted aortic rings, actions not requiring circulating DPP4 substrates, which may be transduced through nitric oxide and the cGMP signaling pathway (196)

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doi: 10.1056/NEJMoa1616011 11 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al

Some require daily injections, while others are long-acting and administered only once weekly