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Ambery PD, Klammt S, Posch MG, Petrone M, Pu W, Rondinone C, et al

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Absolute contraindications to phentermine, regardless of GLP-1 status: Uncontrolled hypertension History of coronary artery disease or heart failure Uncontrolled hyperthyroidism Glaucoma History of substance use disorder (phentermine is Schedule IV) Use within 14 days of MAO inhibitors Pregnancy or planning pregnancy Age over 65 (relative contraindication) The GLP-1 alone may still be appropriate in many of these scenarios

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Nezbedova P, Brtko J

High levels of glucose stimulated S6K activity in both nuclei, and the presence of GLP-1 reversed such activation