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However, the insulinotropic effect of incretins is diminished in type 2 diabetic patients, due in part to reduced expression of incretin receptors as a consequence of glucotoxicity

the overall 12-month discontinuation rate for GLP-1 agonists is estimated at 36.5%, with higher rates observed in patients with obesity alone compared to those with type 2 diabetes

Kipp M, Clarner T, Dang J, Copray S, Beyer C

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2020, Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis, National Library of Medicine, accessed 15 February 2023, Fielding, R et al

Assess effects for several days before increasing