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Most common semaglutide side effects include: Nausea Constipation Diarrhea Vomiting Stomach discomfort Fatigue As with tirzepatide, most symptoms ease within a few weeks

These symptoms, which generally occur at the start of treatment and during dose escalation, are mostly mild to moderate in severity and tend to diminish over time

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The urge to indulge in comfort foods can also lead to overconsumption of high-fat or sugary items, which can disrupt digestion