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If your body cannot absorb the nutrient, the quality of the ingredient becomes irrelevant

[1] [2] Patients with severe gastrointestinal disease, including gastroparesis, should use semaglutide with caution

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Even the mainstay of any vitamin regimen, vitamin C, becomes less bioavailable with increased doses, especially above 250 mg.1 For example, taking either 1 or 2 grams of powdered vitamin C will yield similar blood levels, as the majority of vitamin C will pass through the body