ROS are key factors in the regulation of osteoclast differentiation ( Figure 3 )
(PubMed) Avoid if pregnant/breastfeeding, have liver/kidney disease, asthma or severe allergies, immune compromise, or if you cannot confirm product sterility and source
In the brain, energy metabolism is tightly regulated as neurons are dependent on glucose as their primary energy source, but are unable to store sufficient quantities of glycogen to meet demand [118]
Moreover, in models of ischemiareperfusion injury and in KEAP1-inactivated lung cancer, inhibition or genetic ablation of CoQ biosynthetic enzymes restored sensitivity to ferroptosis or radiotherapy 115,116 , underscoring the reliance of some cancer cells on an abundant CoQ pool for redox defense and survival
BAs may modulate gut microbiota through antimicrobial properties, with deconjugated BAs produced by bacterial bile salt hydrolases being much less toxic to gut bacteria
It also has a high safety profile at recommended dosages