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Tirzepatide engages GIP near the strength of the natural hormone but activates GLP-1 about 18 times more weakly than natural GLP-1. After accounting for protein binding in blood, the drug is roughly 20-fold GIP-forward and has no meaningful glucagon activity

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This doesn't necessarily indicate risk, but it does mean we're relying on individual safety profiles and clinical judgment

The data showed that starting at 4 mg nearly doubled gastrointestinal side effects (nausea, vomiting, diarrhea) compared to starting at 2 mg

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Alongside that, it describes weekly provider check-ins during the taper phase rather than leaving the process unmonitored