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Discontinuation because of gastrointestinal adverse reactions occurred in 3.1% and 3.8% of treated patients versus 0.4% on placebo, so most people who experienced symptoms continued

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Vascular lesions : These are problems with the blood vessels themselves, which could be hereditary or due to chronic kidney or heart disease

Most patients find that with proper titrationthe process of slowly increasing the medication dosethe body adapts well to the combination