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Thus, depolarizing agents such as colistin should not increase ROS production

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In particular, 6 of the 10 oxidative phosphorylation genes demonstrated to be altered in SW837 cells were genes of Complex I, supporting the role of metformin as a Complex I inhibitor in rectal cancer

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Glutathione oxidized can be reduced to GSH under the action of glutathione reductase in the presence of NADPH for cellular antioxidant defense [2]