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A defining feature of flavonols is the hydroxyl group at the 3-position

387,388,389 Oxidation-reduction modifications also participate in the regulation of AMPK activation, where Cys130 and Cys174 of AMPK can form disulfide bonds through oxidation, thereby impeding the binding of AMPK kinase to AMPK and subsequent AMPK activation

GIP -uremia , GIP nephrectomy, (clearance) GIP ( Meier ' -Diabetes 2004)

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