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Propensity score matching incorporated demographics, comorbidities, ocular history and medications

Data from human iPSC-derived cell types have shown that neuronal ApoE4 promotes tau phosphorylation and cell death to a greater extent than ApoE3 (Wadhwani et al., 2019)

However, most of this research has been conducted in animal models, and human safety and efficacy data are limited

Putting these pieces together: studies show low rates of issues, real-world research indicates a stronger signal compared to other treatments in some cases, and reports highlight rare autoimmune reactions

That particular study found that at the 86-week mark, most if not all participants had put back all of their lost weight except for 3 pounds

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