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These results suggested that by preventing Sab phosphorylation, fomepizole interrupted the amplified oxidative stress cycle, stopped ROS production and halted activation of ASK1/2 ( Figure 23 )

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Author contributions HW: Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Software, Validation, Visualization, Writing original draft, Writing review & editing

Mitochondrial metabolism is required to continuously adjust to stress or challenging conditions to sustain the bioenergetic levels essential for cellular functions