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Clinically, B12 shots have long been used to treat cyanide poisoning

They represent a shared biochemical denominator: persistent oxidative stress combined with impaired endogenous antioxidant defense

However, the underlying mechanism is not yet clear

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The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

J Pharm Exp Therap 244(3):1036-1039