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But rapid weight loss often means losing muscle, energy, and momentum too

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Semaglutide was initiated at a dose of 0.25 mg once weekly, and the dose was increased every 4 weeks in accordance with recommended dosing (from 0.25 mg to 0.5 mg, 1.0 mg, 1.7 mg, and 2.4 mg) until the 2.4-mg dose was reached

The Phase 2 COURAGE trial reported that about 35% of semaglutide-induced weight loss was from lean mass ( Regeneron Newsroom )

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The GLP1R rs6923761 variant, assessed in genetic panels, influences GLP-1 receptor sensitivity and may contribute to variable nausea responses