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Effects may self-resolve, or abate with a reduced dose, gradually increasing back to the therapeutic target

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2017;24(6):14101417 DOI: 10.1016/j.sjbs.2016.08.010 18

Use the conservative rule: reconstitute only what is needed, refrigerate at 2-8 C, protect from light, label the date, and discard around 28 days or sooner if the solution changes appearance or sterility is compromised