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In monolayer differentiated intestinal epithelial cells (cdx2-ECE), butyrate enhances intestinal barrier function by increasing the expression of the TJ protein claudin- 1 (90)

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The conversion of glutamine to glutamate and then to -KG with the enzyme glutaminase (GLS), its use in the synthesis of energy and various biomolecules is called the glutaminolysis pathway (Fig

The translocation of these noxious metabolites into circulation can induce oxidative stress and systemic inflammation, subsequently aggravating renal inflammation and fibrosis

Structural changes in this active center are closely linked to the enzymes catalytic activity, which determines its ability to oxidize tyrosine 15