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Incubation was carried out overnight (12 h) at 4 C under gentle rotation

As of January 2026, the Wegovy Pill (oral semaglutide 25 mg) is FDA-approved and available in the US

Given that a substantial portion of the reports originated from the United States, further investigation is warranted to understand these reporting trends and the maturity of reporting systems within various regional or cultural contexts

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GIP receptor agonism is hypothesised, based on preclinical and early clinical data, to complement GLP-1 effects on insulin secretion and may influence adipose tissue metabolism, though the precise contribution in humans remains an area of active investigation