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those with normal levels are unlikely to see significant changes in energy or well-being from supplementation

Additional symptoms include poor balance, confusion, difficulty remembering, and depression

While mechanistically interesting, stacking three or more compounds dramatically increases complexity, cost, and potential for unexpected interactions

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This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes

Doctors should hand out B12 shots almost by default, based on symptoms alone