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The most reported side effects include: Mild to moderate nausea, particularly in the first few weeks Digestive discomfort (bloating, constipation, or loose stools) Occasional fatigue during dose escalation periods The important context: These effects are typically temporary and resolve as your body adapts Proper dose titration significantly reduces severity Serious adverse events are rare and were closely monitored in clinical trials Conditions that may make tirzepatide inappropriate include certain thyroid disorders, specific endocrine conditions, and other contraindications identified during a medical evaluation