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Shin, Evaluation of the antioxidant and cytotoxic activities of zinc oxide nanoparticles synthesized using Scutellaria baicalensis root

In contrast, the combination of CB-839/telaglenastat with multiple tyrosine kinase receptor inhibitor cabozantinib did not improve the efficacy of cabozantinib in patients with advanced RCC in the CANTATA phase II randomized clinical trial (NCT03428217), although it was well tolerated [163]

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By prolonging the cell cycle, breast cancer cells expressing Bcl-2 exhibit an increased doubling time, a reduced S-phase fraction, and accumulation in the G1/G0 phase, processes that are regulated by distinct genetic pathways (51, 52)