Among 3931 people in a US cohort aged 65 years and older, consumption of foods of animal origin was estimated from detailed questionnaires, and blood levels of TMAO-related metabolites were measured during the course of the study with an average duration of 12.5 years
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Other significant factors include genetic variations, nutritional deficiencies of cofactors (copper, zinc, manganese), overwhelming oxidative stress, and inflammatory conditions that alter SOD expression or activity