Although all evaluated GLP-1RAs were associated with lower odds of SUD outcomes, the magnitude of association varied across some agents
Cupp ME, Nayak SK, Adem AS, Thomsen WJ
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By contrast, peptides such as PYY and apelin were discontinued primarily due to formulation limitations or tolerability at supraphysiologic dosespharmacologic rather than biological failuresand therefore meet criteria for re-evaluation
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