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Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]
Back Drucker, DJ, Holst, JJ (28 March 2023) 'The expanding incretin universe: from basic biology to clinical translation', Diabetologia , 66, 1765-29
The notable structural differences in the x, y, and z directions suggested that the incorporation of amikacin might compromise the membrane stability of the liposomes
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