To further validate the synergistic effects of multi-strain probiotics, a randomized double-blind placebo-controlled trial involving 104 women with PCOS was conducted over six months, employing a formulation combining seven probiotic strains ( Lactobacillus acidophilus UBLA-34, Lactobacillus rhamnosus UBLR-58, etc.) with fructooligosaccharides, alongside dietary and lifestyle modifications
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Statistical analysis Data are expressed as mean standard deviation, unless indicated otherwise
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Evidence from animal and human models suggests that gut microbial communities play a role in neuroinflammation and -synuclein aggregation
For instance, overexpression of -syn increases the levels of monounsaturated fatty acids, altering the membrane lipid balance and exacerbating toxicity (139)
