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Heart Rate Changes: Unlike some older loss medications , triple agonists can cause a modest increase in heart rate (5-10 bpm), which requires monitoring in patients with pre-existing heart disease

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It is used off-label

GLP-1 binds the G-protein-coupled GLP-1 receptor (GLP-1R) on -cells, activating cAMP/PKA and Epac2

This educational protocol presents a once-daily subcutaneous approach with gradual titration for all vial sizes (5mg, 10mg, 20mg)