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In fact, this study shows that the levels of these molecules are significantly lower in joint fluid than in the blood/plasma and may be incidental to the function of the joints. Jeffrey Zarin, MD Also, there did not seem to be a difference between patients that had arthritis and those that did not, so conclusions about the effect of GLP-1 on arthritis should also be interpreted cautiously, Zarin added

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They work by mimicking the behavior of Glucagon-Like Peptide 1, a naturally occurring hormone that triggers the pancreas to release insulin, slow digestion and reduce appetite and hunger

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Dysesthesia occurred in 8.8% and 20.9% (9 mg and 12 mg, respectively) of patients treated with retatrutide, compared to 0.7% with placebo