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For example, in the SURMOUNT-4 trial, tirzepatide discontinuers were randomized to a placebo, and they were unaware whether they were receiving tirzepatide or not. In real-world settings, the most common reasons for discontinuation are cost or insurance-related issues, and side effects, with the former predominating, he added

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GLP-1 and GLP-1R agonists play an essential role on glucose homeostasis

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In contrast to classic iron deficiency anemia, supplementation alone may not fully correct hemoglobin levels because inflammation continues to impair iron mobilization