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Furthermore, GHK-Cu's role as a cofactor for the antioxidant enzyme superoxide dismutase (SOD) is complemented by its apparent ability to increase the expression of other antioxidant genes, providing a multi-pronged mechanism for investigating oxidative stress mitigation in cell-based assays
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The Ucn3 receptor CRHR2 is specifically expressed in pancreatic SST-secreting cells, but not in other types of pancreatic islet cells, which enables the selective operation of pancreatic SST-secreting cell function using the CRHR2 antagonist astressin 2B (Ast2B) 8,10