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That term reflects the research hypothesis and experimental findings rather than a recognised clinical classification

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The pathogenesis of obesity is multifactorial, but a number of environmental risk factors are thought to critically contribute to the escalating obesity epidemic, notably unhealthy lifestyle behaviors such as excessive intake of processed foods and physical inactivity [6]

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The inhibition of mTORC1 signaling by cystine starvation demonstrated that regulation of this pathway is not limited to essential amino acids 9,10,11,12 , but is also regulated by cysteine availability (Fig

The aberrant transport of UA in the kidneys is a significant pathogenic factor in gouty arthritis (45)