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This cycling approach keeps intracellular NAD+ levels elevated without requiring continuous clinical visits

The tyrosine-derived fragment contributes an aromatic phenolic ring system, while the isoleucine-derived segment introduces a branched aliphatic side chain

[Establishes Cortical Spreading Depression mechanism]

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Funding Open access funding provided by Universit degli Studi di Milano - Bicocca within the CRUI-CARE Agreement

Due to their preclinical testing and lack of comparison with other dual receptor agonists such as tirzepatide, further studies are needed to determine whether the effects of these unimolecular compounds are superior to those of clinically tested drugs