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Additionally, TRZ therapy upregulates proteins involved in synaptic plasticity, such as growth-associated protein 43 (GAP-43) and microtubule-associated protein 2 (MAP2)

Contrave is indicated for long-term use, meaning that if its working for a patient they can stay on it indefinitely, as long as they are able to achieve a 5% total body weight loss at the end of 3 months

Overall, eighteen clinical trials published between 2002 and 2021 were included in the meta-analysis

Self-adjusting may lead to inconsistent results or side effects

The main tests used for the evaluation of TA and TR level as well as to assess GC-dependent side effects, include in vitro molecular profiling of TR and TA-associated genes

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