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J., Donohue, T

Inhibition of renal prostaglandin synthesis can lead to a variety of detrimental effects if kidney function is less than optimal, including fluid and electrolyte disorders, acute renal dysfunction, nephrotic syndrome, interstitial nephritis, and renal papillary necrosis

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The most they could claim to have shown from the EPIC Study's findings was that, for the average MVD-affected dogs (with and without heart enlargement) prior to CHF, pimobendan could delay the onset of CHF longer than dogs receiving a placebo

In a clinical trial of semaglutide injection for weight loss (Wegovy) in patients with T2DM and a BMI of 27 kg/m2 or more, hypoglycemia (defined as a plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients