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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

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IV delivery bypasses the digestive system: nutrients infused into the bloodstream reach higher concentrations than oral supplements

95% CI, 0.75 to 1.32), whereas the use of GLP-1 analogues was linked to an increased risk (6.1 vs

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