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The 1st glutathione-interaction site, also termed glutathione-scaffold site, is rather well defined and comprises several protein areas that altogether contribute to catalysis by interacting with the glutathione moiety of GSSR 7,8,13,14,15,35 , therefore explaining the specificity for the -glutamyl moiety 9,49,50

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4 PAG-sensitivity of CSSC utilization in cultured primary hepatocytes

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GDF15 provides an endocrine signal of nutritional stress in mice and humans