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This is why most vegans and vegetarians need to take vitamin B12 supplements

Vitamin B12 shots are given to prevent or treat vitamin B12 deficiency

2 Vitamin B12 plays several important roles in the body, including: 3 Helping to produce energy by converting food into glucose Maintaining healthy nerve function Making DNA, the genetic material in all cells Helping to form red blood cells Helping enzymes to function as a cofactor Controlling homocysteine levels Vitamin B12 deficiency can lead to several health problems, including anemia, nerve damage, and neurologic symptoms such as memory loss and difficulty concentrating

These data provide researchers with specific metrics to design similar studies

and a 2021 peer-reviewed review on NNMT in obesity and type 2 diabetes noting the absence of human clinical trials

It is studied in preclinical research for its role in metabolic regulation and NAD+ biology