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Yes, hybrid protocols using IM loading doses followed by SubQ maintenance are viable and sometimes advantageous when rapid initial saturation is needed but long-term sustained levels matter more

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they are more likely to result from certain constituents of coffee augmenting endogenous antioxidant defences, such as upregulation of GSH concentration and glutathione-S-transferase (GST) activity (12)

(2026) Zhu et al