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Although genetic methods (i.e., gene knockout and knockdown) are powerful approaches, they often activate compensatory pathways, making it difficult to determine the specific role of each enzyme (Marutani and Ichinose, 2020

However, when Akkermansia muciniphila proliferates excessively, it breaks the intestinal immune homeostasis

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Although autophagy was first considered to perform in a bulk manner, it is now clear that autophagy is mainly a selective process that originally encounters considerable resistance (Mizumura et al., 2014)

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10.3390/jcm10132805 100 ReiserE.LanbachJ.BottcherB.TothB