A diagnosis of GSSD was finally made based on intractable metabolic acidosis, jaundice, hemolytic anemia, hyperbilirubinemia, massive 5-oxoprolinuria, and the presence of compound heterozygous variants in GSS
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In addition, exercise training inhibited inflammasome activation and pyroptosis by shifting microglial polarization from the pro-inflammatory M1 to the anti-inflammatory M2 type (Liu et al., 2022)
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