Improvement in wound healing were seen in normoglycemic mice, suggesting a role independent of glucose control and in-vitro studies have shown that GLP-1RAs may directly improve wound healing, independent of blood glucose control, through the reduction of CRP and MMP-9/TIMP-1 ratio, endothelial protection and angiogenesis secondary to increased AMPK, increased endothelial cell proliferation due to stimulation of CD31+ cells, P13/AKT induced keratinocyte migration, increased vascularity and dermal and epidermal regeneration due to increased phosphorylated eNOS and VEGF R2, as well as increased endothelial progenitor cells, fibroblasts, and myofibroblasts
GLP-1 drugs are intended to be used over the long-term, to treat obesity as a chronic conditionnot in the short-term for a big event, says Ethan Lazarus, MD, an obesity medicine specialist in Denver, CO, and past president of the Obesity Medicine Association
Cholesterol levels already in normal range*
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Any concerns about medication safety should be discussed with a GP, diabetes specialist nurse, or consultant, who can provide evidence-based guidance tailored to individual circumstances
Some individuals may increase more slowly, pause dose increases, or remain at a lower effective dose
