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Serum B12 The graphs show a general trend of quick, initial changes which then slow over time, and that the poorer your initial B12 status is, the more quickly it initially changes

A general framework

Will long-term use in younger populations pose different skeletal risks

Discussion In this prospective study, we analysed the development of thyroid dysfunction in a large number of patients ( n = 209) treated with anti-PD-1 antibodies, and showed that the presence of anti-thyroid antibodies at baseline is a biomarker of the development of destructive thyroiditis and/or hypothyroidism induced by not only nivolumab but also pembrolizumab

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