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Qutier, I

Immunity 52 , 557570.e6 (2020)

Local pain and tenderness at the injection site, urticaria, and angioedema may occur

These include: Inappropriate dosing or frequency Lack of proper diagnosis and monitoring Non-sterile injection technique increasing infection risk Absence of medical supervision for adverse reactions Financial cost without clinical benefit Patients should report any suspected adverse reactions to B12 injections via the MHRA Yellow Card scheme

Notwithstanding its invasiveness, tape stripping is regarded as a reproducible and regulated technique for temporarily diminishing the skin barrier, rendering it a significant instrument for investigating and enhancing liposomal transdermal drug delivery systems

The absence of long-term human data beyond 6 weeks creates uncertainty about chronic use implications