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In addition, IDH1-dependent reductive glutamine metabolism produces NADPH, which decreases mitochondrial ROS during anchorage-independent growth 64

Rapid urbanisation, changing dietary habits and increasingly sedentary lifestyles are transforming what was once an underdiagnosed condition into one of the continent's most pressing public health concerns

[DOI] [PubMed] [Google Scholar] 45.Zhai H., Poblete N., Maibach H

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Daily administration increases the risk of methionine overload, elevated homocysteine, and gastrointestinal side effects without improving fat oxidation beyond what the liver can process

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