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Hypoxia (54) and HIF-1-mediated signaling (48) could induce the production of VEGF in TAM, suggesting that they could be a source of VEGF in the TME and could promote tumor angiogenesis

MDSCs are important in immune suppression induced by inflammatory cytokines (e.g., PGE2), and MDSCs could affect the induction and function of Tregs

Cancer 121(17):2968-75, 2015

Exfoliative cytology is the least expensive and most easily performed diagnostic test

No statistically significant differences were noted between groups regarding serum levels of testosterone, FSH, LH, and prolactin at baseline