is depression a side effect of semaglutide Ozempic Safe if You Have Depression? Semaglutide and Depression Risk: Clinical

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GLP-1 RAs are increasingly recommended by current guidelines as preferable treatments in these groups, and our mechanistic studies on inflammatory pathways reinforce and validate these recommendations

Glucagon-like peptide-1 (GLP-1)-based agents (including GLP-1 analogues and dipeptidyl peptidase 4 inhibitors) have been recently approved as new therapeutic options for patients with type 2 diabetes, based upon the evidence that GLP-1 can stimulate glucose-dependent insulin secretion from pancreatic cells

While effective in lowering blood glucose levels, they carry a risk of hypoglycemia (low blood sugar) and may not be suitable for all patients, especially those with kidney problems

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For semaglutide specifically, the SmPC advises discontinuation at least 2 months before a planned pregnancy due to its long half-life