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The results of immunofluorescence staining of the synovial tissues indicated that, compared with the NC group, the proportion of CD68 + CD86+ M1 macrophages significantly increased in the RA group, while the proportion of CD68 + CD206+ M2 macrophages did not change significantly

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As a result, they lack the same batch testing, sterility checks, and device-based dosing controls as branded pens