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Moderate to Severe Deficiency: For moderate to severe deficiencies, the dosage may increase to 1,000 mcg several times a week initially, followed by a maintenance dose

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Advantages of metformin include the longstanding research supporting its efficacy and safety, an expected decrease in the glycated hemoglobin (HbA1c) level of 1% to 1.5%, low cost, minimal hypoglycemic risk, and potential reductions in cardiovascular (CV) events due to decreased low-density lipoprotein (LDL) cholesterol

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