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Studies in animal models have shown an anorexigenic action of GIP receptor agonism [36] and a recent phase 1 clinical trial with a long-acting GIP RA found that repeated dosing for 4 weeks induced modest WL (1.9 to 3.1 kg vs

The 8mg dose delivers impressive results with better tolerability than 12mg

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Combining phentermine with semaglutide or tirzepatide is sometimes done but requires careful monitoring