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By activating both receptors simultaneously, tirzepatide produces: More powerful appetite suppression than GLP-1 stimulation alone Greater improvements in insulin sensitivity Larger reductions in body fat, particularly visceral (abdominal) fat Faster and larger HbA1c reductions in people with type 2 diabetes This dual mechanism is the pharmacological reason tirzepatide produces greater weight loss than semaglutide in every major clinical trial conducted to date