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First, while correlative data are compelling, definitive causal evidence establishing that DSSs clinical benefits are directly mediated through the normalization of this specific biomarker network requires further validation

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In 2006, Harris and colleagues (2006) were the first to demonstrate that oral ingestion of 3.2 or 6.4 g/day of beta-alanine (or an isomolar amount of supplemented carnosine (13.0 g/day)) resulted in a 40-60% increase in muscle carnosine in humans

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